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Article

Pitfalls and Challenges in the Detection of ZNF384 Rearrangements by Fluorescence in Situ Hybridization.

Genes, chromosomes & cancer - 1 Aug 2026

Nebral Karin, König Margit, Haslinger Sabrina, Inthal Andrea, Schinnerl Dagmar, Plank Maya-Marisol, Fortschegger Klaus, Attarbaschi Andishe, Haas Oskar A, Strehl Sabine

Abstract excerpt

Fusion genes involving ZNF384 define a rare subtype of B-cell acute lymphoblastic leukemia with favorable to intermediate outcomes. ZNF384 rearrangements (ZNF384-r) with diverse partner genes are often cryptic, making whole-transcriptome sequencing (RNA-seq) the most sensitive technique for their detection. For patient screening and routine diagnostics, fluorescence in situ hybridization (FISH) using a dual-color...

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Share to Gene Rearrangement
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 42629621
DOI: 10.1002/gcc.70161
PMCID: PMC13498722

Genes

ZNF384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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