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Beyond Binary FISH Results: Targeted NGS Provides Deeper Characterization of MYC and Broader Genomic Alterations in DLBCL.

Molecular diagnosis & therapy - 1 May 2026

Bastos-Oreiro Mariana, de Córdoba-Oñate Sara Fernández, de la Iglesia-San Sebastián Ismael, Díaz-Crespo Francisco, Lavilla María Chicano, Triviño Juan Carlos, González Raquel Fernández, López-Esteban Miguel, Gómez-Llobel Marina, Caldas Paula Fernández, Silva Pablo, Menárguez Javier, Sanz Ramón García, Buño Ismael, Martínez-Laperche Carolina

Abstract excerpt

INTRODUCTION: Rearrangements involving MYC, BCL2, and BCL6 are central to the genetic classification and risk stratification of diffuse large B cell lymphoma (DLBCL). In routine practice, these alterations are primarily assessed by fluorescence in situ hybridization (FISH), which provides limited diagnostic information and lacks information on partner genes, breakpoint architecture, or clonal complexity. METHODS:...

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Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to High-Throughput Nucleotide Sequencing

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 41973147
DOI: 10.1007/s40291-026-00846-5

Genes

MYC
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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