ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia

Abstract excerpt

Zinc finger protein 384 ( ZNF384) encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have been detected in ALL. These include E1A-binding protein P300 ( EP300), CREB-binding protein ( CREBBP), transcription factor 3 ( TCF3), TATA-box binding protein...