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Zinc finger protein 384 (ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia.

Leukemia & lymphoma - 1 Dec 2022

Sudutan Tugce, Erbilgin Yucel, Hatirnaz Ng Ozden, Karaman Serap, Karakas Zeynep, Kucukcankurt Fulya, Celkan Tiraje, Timur Cetin, Ozdemir Gul Nihal, Hacısalihoglu Sadan, Gelen Sema Aylan, Sayitoğlu Müge

Abstract excerpt

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment decisions. Patients with ZNF384 rearrangements had a distinct expression profile regardless of their diagnosis, BCP-ALL or mixed phenotype acute leukemia (MPAL) and defined as a new subtype of ALL. In...

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PMID: 35921545
DOI: 10.1080/10428194.2022.2095630

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