Article

Integrated molecular approach including single-cell FISH enables accurate detection of genetic rearrangements, classification, and identification of novel variants in pediatric brain tumors

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>INTRODUCTION: Pediatric brain tumors (PBTs) are a heterogeneous group of neoplasms. The WHO classification highlights the relevance of genetic and epigenetic alterations in defining molecular subtypes. This study investigated key rearrangements (<italic>MYB</italic>, <italic>MYBL1</italic>, <italic>ZFTA</italic>, <italic>YAP1</italic>, <italic>MN1</italic>) and fusions (<italic>KIAA1549...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9bd7c19-bd72-5513-8950-6ae5d8600322
DOI: 10.21203/rs.3.rs-7244481/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated molecular approach including single-cell FISH enables accurate detection of genetic rearrangements, classification, and identification of novel variants in pediatric brain tumorsDOI 10.21203/rs.3.rs-7244481/v1Read

Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra.Semantic proximity Read

Multiplex Detection of Pediatric Low-Grade Glioma Signature Fusion Transcripts and Duplications Using the NanoString nCounter System.Semantic proximity Read

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.Semantic proximity Read

The Swedish Childhood Tumor Biobank: Systematic collection and molecular characterization of all pediatric CNS and other solid tumors in SwedenSemantic proximity Read

Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making - A Selected Case Series.Semantic proximity Read

Novel amplifications in pediatric medulloblastoma identified by genome-wide copy number profiling.Semantic proximity Read

OpenPBTA: An Open Pediatric Brain Tumor AtlasSemantic proximity Read

TUCAN: Ultra-fast methylation-based classification of pediatric solid tumors and lymphomasSemantic proximity Read

Invited Review: DNA methylation‐based classification of paediatric brain tumoursSemantic proximity Read

DNA methylation profiling as a model for discovery and precision diagnostics in neuro-oncologySemantic proximity Read

Optical genome mapping identifies a novel pediatric embryonal tumor with a ZNF532::NUTM1 fusionSemantic proximity Read

Development, optimization and application of a Universal Fluorescence Multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumorsSemantic proximity Read