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Article

A novel class of ZNF384 aberrations in acute leukemia

16 Sept 2021

Abstract excerpt

Fusion of the ZNF384 gene as the 3' partner to several different 5' partner genes occurs recurrently in B-cell precursor acute lymphoblastic and mixed phenotype B/myeloid leukemia. These canonical fusions (ZNF384r) contain the complete ZNF384 coding sequence and are associated with a specific gene expression signature. Cases with this signature, but without canonical ZNF384 fusions (ZNF384r-like cases), have been...

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PMID: 34529760
DOI: 10.1182/bloodadvances.2021005318

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