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Article

Genomic landscape of ERCC alterations in breast and gynecological cancers: implications for targeted therapy and VUS reclassification.

Molecular biology reports - 21 Aug 2026

Canbek Sezin, Karaağaç Melisa, Ermiş Aleyna, Türkan Şeref, Topal Cumhur Selçuk, İlhan Nurullah, Yalçınkaya Cem, Ezberci Fikret

Abstract excerpt

BACKGROUND: The Excision Repair Cross-Complementation (ERCC) gene family is critical for the Nucleotide Excision Repair (NER) pathway, yet its clinical utility in solid tumors remains underexplored. Impaired DNA repair via ERCC alterations drives tumorigenesis and influences response to DNA-damaging therapies. This study maps the clinical and genomic landscape of ERCC mutations to highlight their potential as...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genital Neoplasms, Female

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Source

Identifiers

PMID: 42627456
DOI: 10.1007/s11033-026-12640-x

Genes

BRCA1
ERCC2
ERCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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