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ERCC2 mutations alter the genomic distribution pattern of somatic mutations and are independently prognostic in bladder cancer.

Cell genomics - 14 Aug 2024

Barbour Jayne A, Ou Tong, Yang Haocheng, Fang Hu, Yue Noel C, Zhu Xiaoqiang, Wong-Brown Michelle W, Wong Yuen T, Bowden Nikola A, Wu Song, Wong Jason W H

Abstract excerpt

Excision repair cross-complementation group 2 (ERCC2) encodes the DNA helicase xeroderma pigmentosum group D, which functions in transcription and nucleotide excision repair. Point mutations in ERCC2 are putative drivers in around 10% of bladder cancers (BLCAs) and a potential positive biomarker for cisplatin therapy response. Nevertheless, the prognostic significance directly attributed to ERCC2 mutations and...

Topics

Humans
Urinary Bladder Neoplasms
Xeroderma Pigmentosum Group D Protein
Prognosis
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39096913
DOI: 10.1016/j.xgen.2024.100627
PMCID: PMC11406173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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