Novel environmental contaminant 6PPD-quinone promotes malignant phenotypes in colorectal cancer cells and identifies candidate response-associated genes.

doi:10.1016/j.cbi.2026.112307

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Article

Novel environmental contaminant 6PPD-quinone promotes malignant phenotypes in colorectal cancer cells and identifies candidate response-associated genes.

Chemico-biological interactions - 1 Oct 2026

Su Shuangyan, Liao Yuxing, Wu Bihua, Li Yuwei, Lou Fenglin, Mei Zhenghao, Guo Le

Abstract excerpt

6PPD-quinone (6PPDQ), an oxidative transformation product of the widely used tire antioxidant 6PPD, is a ubiquitous environmental contaminant with bioaccumulation potential and widespread human exposure. Recent epidemiological evidence indicates a positive association between urinary 6PPDQ levels and colorectal cancer (CRC) risk; however, its biological effects on CRC-related phenotypes and associated molecular...

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Topics

Humans
Colorectal Neoplasms
Phenotype
Caco-2 Cells
Cell Proliferation
Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HCT116 Cells

Environmental Pollutants

Molecular Dynamics Simulation

Gene Expression Regulation, Neoplastic

Cell Movement

Quinones

Phenylenediamines

Benzoquinones

Source

Open in PubMed

Identifiers

PMID: 42624235
DOI: 10.1016/j.cbi.2026.112307

Genes

CPT2
SHC2
STK35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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