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Article

6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish.

Journal of hazardous materials - 5 Aug 2023

Zhang Shu-Yun, Gan Xiufeng, Shen Baoguo, Jiang Jian, Shen Huimin, Lei Yuhang, Liang Qiuju, Bai Chenglian, Huang Changjiang, Wu Wencan, Guo Ying, Song Yang, Chen Jiangfei

Abstract excerpt

The automobile tire antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its quinone metabolite 6PPDQ have recently received much attention for their acute aquatic toxicity. The present study investigated the mechanistic developmental toxicity of 6PPD and 6PPDQ in embryonic zebrafish. Neither compound induced significant mortality but significantly decreased spontaneous embryo movement and...

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PMID: 37182464
DOI: 10.1016/j.jhazmat.2023.131601

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