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Article

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health.

Toxicological sciences : an official journal of the Society of Toxicology - 28 Sept 2023

Davis Allan Peter, Wiegers Thomas C, Wiegers Jolene, Wyatt Brent, Johnson Robin J, Sciaky Daniela, Barkalow Fern, Strong Melissa, Planchart Antonio, Mattingly Carolyn J

Abstract excerpt

The molecular mechanisms connecting environmental exposures to adverse endpoints are often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database (CTD), we developed a bioinformatics approach that integrates manually curated, literature-based interactions from CTD to generate a "CGPD-tetramer": a 4-unit block of information organized as a step-wise molecular mechanism linking an initiating...

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PMID: 37486259
DOI: 10.1093/toxsci/kfad069
PMCID: PMC10535784

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