Article

Evaluating the Carcinogenic Potential and Molecular Mechanisms of 6PPDQ in the Human Stomach Using Organoids and Bulk Sequencing Data: A Multi-Machine Learning Approach Combined with Computational Simulation

2026-03-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The environmental contaminant 6PPD-quinone (6PPDQ), a tire rubber antioxidant derivative, has emerged as a potential health hazard, yet its association with gastric cancer (GC) remains unexplored. This study investigates the molecular mechanisms underlying 6PPDQ-induced GC using network toxicology. <bold>Methods:</bold> 6PPDQ targets were retrieved from Pha...

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Literature Corpus work: 105fda22-da78-58c8-9836-0e53935a6300
DOI: 10.21203/rs.3.rs-9015987/v1

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Evaluating the Carcinogenic Potential and Molecular Mechanisms of 6PPDQ in the Human Stomach Using Organoids and Bulk Sequencing Data: A Multi-Machine Learning Approach Combined with Computational SimulationDOI 10.21203/rs.3.rs-9015987/v1Read

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