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Article

Reactive Oxygen Species as Mediators of Disease Progression and Therapeutic Response in Colorectal Cancer

15 Feb 2023

Abstract excerpt

Significance: Reactive oxygen species (ROS) are critical to normal cellular function with redox homeostasis achieved by balancing ROS production with removal through detoxification mechanisms. Many of the conventional chemotherapies used to treat colorectal cancer (CRC) derive a proportion of their cytotoxicity from ROS generation, and resistance to chemotherapy is associated with elevated detoxification...

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PMID: 36792932
DOI: 10.1089/ars.2022.0127

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