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Article

Nuclear Factor Erythroid 2-Related Factor 2 in Chronic Obstructive Pulmonary Disease Progression: Regulation of Macrophage Polarization and Hyaluronic Acid Metabolism.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Bai Ge, Wang Jiaqi, Wen Qianmei, Huang Yuning, Li Haiqing, Xu Yanhui, Liu Yiyi, Yi Erkang, Wu Fan, Cui Jieda, Mei Xinyue, Zhang Yuxia, Zhou Yumin, Sun Ruiting, Ran Pixin

Abstract excerpt

Background: Alveolar microenvironment-driven macrophage polarization critically influences chronic obstructive pulmonary disease (COPD) progression. Nuclear factor erythroid 2-related factor 2 (NRF2), a key transcription factor, regulates macrophage polarization, suppresses inflammation, and promotes cellular repair. However, its role in macrophage-mediated inflammation and metabolic regulation, particularly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42614776
DOI: 10.2147/COPD.S608922
PMCID: PMC13484630

Genes

CD44
CS
CD74
CCL7
CXCL16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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