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Article

Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD

20 Aug 2019

Abstract excerpt

BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response plays a critical role in the protection of lung cells to oxidative stress by upregulating antioxidant genes in response to tobacco smoke. There is a critical gap in our knowledge about Nrf-2...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 31429757
DOI: 10.1186/s12931-019-1164-1

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