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Article

Tumor Microenvironment Properties are Associated With Low CD68-positive Cell Infiltration and Favorable Disease-free Survival in EGFR-mutant Lung Adenocarcinoma.

Clinical lung cancer - 1 Sept 2018

Gong Zhihua, Chen Junying, Cheng Jia-Nan, Sun Chengdu, Jia Qingzhu, Diao Xinwei, Zhu Bo

Abstract excerpt

BACKGROUND: The benefits of immune checkpoint inhibitors for first-line treatment in patients with lung adenocarcinoma harboring EGFR mutations are unclear. The effects of ICIs depend on the tumor microenvironment (TME). Differences in TME properties between mutant and wild-type EGFR have not been fully characterized. PATIENTS AND METHODS: We collected 105 surgically resected (50 EGFR mutated and 55 EGFR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29628320
DOI: 10.1016/j.cllc.2018.03.011

Genes

EGFR
MMP9
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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