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Article

Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naïve lung adenocarcinomas.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2023

Goldschmid Hannah, Kluck Klaus, Ball Markus, Kirchner Martina, Allgäuer Michael, Winter Hauke, Herth Felix, Heußel Claus-Peter, Pullamsetti Soni Savai, Savai Rajkumar, Yong Timothy Tay Kwang, Schirmacher Peter, Peters Solange, Thomas Michael, Christopoulos Petros, Budczies Jan, Stenzinger Albrecht, Kazdal Daniel

Abstract excerpt

OBJECTIVE: Intratumoral heterogeneity was found to be a significant factor causing resistance to lung cancer therapies, including immune checkpoint blockade. Lesser is known about spatial heterogeneity of the tumor microenvironment (TME) and its association with genetic properties of the tumor, which is of particular interest in the therapy-naïve setting. MATERIALS AND METHODS: We performed multi-region sampling...

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Identifiers

PMID: 37141769
DOI: 10.1016/j.lungcan.2023.107212

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