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Article

Parallel Mapping of Antibiotic Resistance Alleles in Escherichia coli.

PloS one - 1 Jan 2016

Weiss Sophie J, Mansell Thomas J, Mortazavi Pooneh, Knight Rob, Gill Ryan T

Abstract excerpt

Chemical genomics expands our understanding of microbial tolerance to inhibitory chemicals, but its scope is often limited by the throughput of genome-scale library construction and genotype-phenotype mapping. Here we report a method for rapid, parallel, and deep characterization of the response to antibiotics in Escherichia coli using a barcoded genome-scale library, next-generation sequencing, and streamlined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26771672
DOI: 10.1371/journal.pone.0146916
PMCID: PMC4714920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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