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Article

Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT).

Nature communications - 17 Aug 2026

Zhou Felix Y, Jacobs Brittany-Amber, Norton-Steele Adam, Han Xiaoyue, Zhou Linna, Carroll Thomas M, Ruiz Puig Carlos, Chadwick Joseph, Qin Xiao, Lisle Richard, Marsh Lewis, Byrne Helen M, Harrington Heather A, Lu Xin

Abstract excerpt

Live cells in tissue are plastic, phenotypically dynamic, and modify their function in response to genetic and environmental perturbations. To unleash the power of live-cell imaging to identify phenotype-genotype-function coupling over time, we report the development of a standardized Shape-Appearance-Motion (SAM) "phenome" and SAM-Phenotype-Observation-Tool (SPOT), that act as an image-"transcriptome" and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42608409
DOI: 10.1038/s41467-026-75506-7
PMCID: PMC13482367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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