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Development of a universal imaging "phenome" using shape, appearance and motion (SAM) features and the SAM Phenotype Observation Tool (SPOT).

Nature communications - 17 Aug 2026

Zhou Felix Y, Norton-Steele Adam, Marsh Lewis, Byrne Helen M, Harrington Heather A, Lu Xin

Abstract excerpt

Cells are plastic, highly heterogeneous and change over time. High-content timelapse imaging promises to reveal dynamic cell behaviors, enabling more accurate identification of cell state and cell fate prediction for biological hypothesis generation and perturbation screens. To empower live-cell imaging based screening, we report the development of (1) a Shape, Appearance, Motion (SAM) "phenome"; a universal set...

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Identifiers

PMID: 42608400
DOI: 10.1038/s41467-026-75505-8
PMCID: PMC13483437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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