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Article

Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model.

Cell stem cell - 1 May 2025

Villaronga-Luque Alba, Savill Ryan G, López-Anguita Natalia, Bolondi Adriano, Garai Sumit, Gassaloglu Seher Ipek, Rouatbi Roua, Schmeisser Kathrin, Poddar Aayush, Bauer Lisa, Alves Tiago, Traikov Sofia, Rodenfels Jonathan, Chavakis Triantafyllos, Bulut-Karslioglu Aydan, Veenvliet Jesse V

Abstract excerpt

Considerable phenotypic variation under identical culture conditions limits the potential of stem-cell-based embryo models (SEMs) in basic and applied research. The biological processes causing this seemingly stochastic variation remain unclear. Here, we investigated the roots of phenotypic variation by parallel recording of transcriptomic states and morphological history in individual structures modeling...

Read the complete abstract on PubMed

Topics

Animals
Mice
Phenotype
Embryo, Mammalian
Single-Cell Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Models, Biological

Glycolysis

Transcriptome

Stem Cells

Oxidative Phosphorylation

Source

Identifiers

PMID: 40245869
DOI: 10.1016/j.stem.2025.03.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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