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Article

TP53 mutations predict poor breast cancer-specific survival in ER-positive breast cancer patients.

Cancer epidemiology - 1 Oct 2026

Ragnarsdottir S, Frick E A, Stefansson O A, Gudjonsson T, Tryggvadottir L, Aspelund T, Bjarnadottir O, Vidarsdottir L, Sigurdsson S

Abstract excerpt

BACKGROUND: TP53 mutations are among the most frequent genetic alterations in breast cancer and are strongly associated with aggressive tumor features and poor outcome. Although TP53 mutations occur across all major breast cancer subtypes, their prognostic significance appears to vary according to estrogen receptor (ER) status and remains incompletely defined. METHODS: Breast cancer-specific survival (BCSS) was...

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Source

Identifiers

PMID: 42607633
DOI: 10.1016/j.canep.2026.103204

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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