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Evaluation of MMP-2 (-1306C/T and -735C/T), MMP-9 (-1562C/T) and TNF-alpha (-308G/A) promoter variants in recurrent spontaneous abortion.

Human immunology - 1 Oct 2026

Chowdhury Animesh, Das Ratan Kumar, Chowdhury Soham, Lama Manoj

Abstract excerpt

OBJECTIVE: The present study was undertaken to determine the association of genetic variants of MMP-2 (-1306C/T and -735C/T), MMP-9 (-1562C/T), and TNF-α (-308G/A) with RSA risk or protection. METHODS: 80 patients and 110 controls were enrolled for the study. Genotyping was carried out using PCR-RFLP method. Serum MMP-2 and MMP-9 activities were assessed by gelatin zymography. Data were analyzed statistically...

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PMID: 42594730
DOI: 10.1016/j.humimm.2026.112040

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TNF

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