Article
NEP1-40 alleviates behavioral phenotypes and promote oligodendrocyte progenitor cell differentiation in the hippocampus of cuprizone-induced demyelination mouse model.
Neuroscience letters - 23 Apr 2020
Liu Qiang, Lv Hao-Wen, Yang Shu, He Yu-Qing, Ma Quan-Rui, Liu Juan
Abstract excerpt
BACKGROUND: Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role in poor OPCs differentiation in the mouse model of demyelinating disease. METHODS: Mice were...
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