Clinical implication of transcriptional dysregulation in the SHH-GLI pathway involving the GLI1 rs61739569 (T>C) variant toward chronic obstructive pulmonary disease (COPD) in North Indians.

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality globally. Genomic susceptibility factors are acknowledged as critical modulators of disease variability and progression. The Sonic Hedgehog (SHH) pathway regulates epithelial tissue healing, mucin synthesis, and airway remodeling. GLI1 polymorphic variants may influence the manifestations of COPD....

Topics

• Humans
• Pulmonary Disease, Chronic Obstructive
• Zinc Finger Protein GLI1
• Hedgehog Proteins
• Male
• Female