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Article

Association between PTCH1 gene polymorphisms and chronic obstructive pulmonary disease susceptibility in a Chinese Han population: a case-control study.

Chinese medical journal - 5 Sept 2020

Kang Xi, Guo Ting, Liu Lyu, Ding Shui-Zi, Lei Cheng, Luo Hong

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Genome-wide association studies in non-Asian population revealed a link between COPD and mutations in the PTCH1 gene encoding Patched1, a receptor in the Hedgehog signaling pathway important for lung morphogenesis and pulmonary function. The aim of this study was to investigate the association between...

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Identifiers

PMID: 32769486
DOI: 10.1097/CM9.0000000000000858
PMCID: PMC7478574

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