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Article

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.

The European respiratory journal - 1 Jul 2010

Van Durme Y M T A, Eijgelsheim M, Joos G F, Hofman A, Uitterlinden A G, Brusselle G G, Stricker B H Ch

Abstract excerpt

The Hedgehog signalling pathway plays an important role in lung morphogenesis and cellular responses to lung injury. A genome-wide association study has demonstrated that two single nucleotide polymorphisms (SNPs) near the Hedgehog-interacting protein (Hip) gene, SNP identifiers rs1828591 and rs13118928, are associated with risk of chronic obstructive pulmonary disease (COPD). The aim of the present study was to...

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PMID: 19996190
DOI: 10.1183/09031936.00129509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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