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Article

Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella.

Science (New York, N.Y.) - 14 Jul 2006

Navarre William Wiley, Porwollik Steffen, Wang Yipeng, McClelland Michael, Rosen Henry, Libby Stephen J, Fang Ferric C

Abstract excerpt

Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired sequences can decrease fitness unless integrated into preexisting regulatory networks. We found that the histone-like nucleoid structuring protein (H-NS) selectively silences horizontally acquired genes by targeting sequences with GC content lower than the resident genome. Mutations in hns are lethal in Salmonella unless...

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Source

Identifiers

PMID: 16763111
DOI: 10.1126/science.1128794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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