Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution.

doi:10.1016/j.molbiopara.2024.111647

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Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution.

Molecular and biochemical parasitology - 1 Dec 2024

Vargas-Maya Naurú Idalia, Maunakea Alika K, Ramírez-Montiel Fátima Berenice, Sultana Razvan, Peres Rafael, Macías-Cervantes Quetzalli Xiadany, Medina-Nieto Ana Laura, Rangel-Serrano Ángeles, Martínez-Álvarez José A, Páramo-Pérez Itzel, Anaya-Velázquez Fernando, Padilla-Vaca Felipe, Franco Bernardo

Abstract excerpt

Entamoeba histolytica, an intestinal parasite of global significance, poses substantial health risks with its associated high morbidity and mortality rates. Despite the current repertoire of molecular tools for the study of gene function in, the regulatory mechanisms governing its pathogenicity remain largely unexplored. This knowledge gap underscores the need to elucidate key genetic determinants orchestrating...

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PMID: 39002760
DOI: 10.1016/j.molbiopara.2024.111647

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