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Article

4-FPAC-Modulated Tumor-Associated Macrophage Conditioned Media Suppresses Malignant Phenotypes and Promotes Cell-Cycle Arrest and Apoptosis in NSCLC.

Journal of biochemical and molecular toxicology - 1 Aug 2026

Singh Anjali, Danes Dhanush, Balakrishnan Suresh

Abstract excerpt

Non-small cell lung cancer (NSCLC) progression is strongly influenced by tumor-associated macrophages (TAMs), which frequently acquire an M2-like phenotype that promotes proliferation, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, and therapy resistance. Previous studies from our group established the direct cytostatic and macrophage-polarizing effects of the synthetic coumarin derivative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42573059
DOI: 10.1002/jbt.71066
PMCID: PMC13455089

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NANOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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