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Article

Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene.

Oncotarget - 28 Jun 2016

Huang Wen-Chien, Chan Mei-Lin, Chen Ming-Jen, Tsai Tung-Hu, Chen Yu-Jen

Abstract excerpt

Tumor-associated macrophages (TAMs) polarized to the M2 phenotype play key roles in tumor progression in different cancer types, including lung cancer. MUC1 expression in various types of cancer is an indicator of poorer prognosis. Elevated MUC1 expression has been reported in inflammatory lung macrophages and is associated with lung cancer development. Here, we investigated the role of M2-polarized TAMs...

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Identifiers

PMID: 27276704
DOI: 10.18632/oncotarget.8101
PMCID: PMC5129938

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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