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Article

Culture supernatants of cervical cancer cells induce an M2 phenotypic profile in THP-1 macrophages.

Cellular immunology - 1 Dec 2016

Pedraza-Brindis Eliza Julia, Sánchez-Reyes Karina, Hernández-Flores Georgina, Bravo-Cuellar Alejandro, Jave-Suárez Luis Felipe, Aguilar-Lemarroy Adriana, Gómez-Lomelí Paulina, López-López Brenda Anahí, Ortiz-Lazareno Pablo Cesar

Abstract excerpt

Patients with cervical cancer (CxCa) typically present an infiltrate of tumor-associated macrophages, which is associated with a poor prognosis. We found that CxCa cell lines (HeLa, SiHa, and C-33A) secreted factors involved in regulating tumor growth including IL-6, IL-4, PDGFAA, HGF, VEGF, ANG-2, and TGF-β3. We assessed the effects of culture supernatants from these cell lines on macrophages derived from the...

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Share to Antigens, Differentiation, Myelomonocytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27502363
DOI: 10.1016/j.cellimm.2016.07.001

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ANG
HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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