Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cohort next-generation sequencing analysis of 713 anaplastic thyroid carcinomas: unreported gene alterations and actionable targets.

American journal of clinical pathology - 4 Aug 2026

Zhang Xiaoming, Chen Naiwei, Claxton Sarah, Kovalenko Mikhail, Pavlick Dean C, Hiemenz Matthew C, Dooley Laura M, Hammer Richard D

Abstract excerpt

OBJECTIVES: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal thyroid malignancies, with limited effective treatment options. We aimed to identify previously unreported gene alterations and evaluate the potential for clinically actionable targeted therapies in ATC using the largest single next-generation sequencing (NGS) cohort to date. METHODS: This retrospective genomic analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDKN2A gene

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to Thyroid Carcinoma, Anaplastic

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 42569949
DOI: 10.1093/ajcp/aqag092

Genes

MTAP
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cohort next-generation sequencing analysis of 713 anaplastic thyroid carcinomas: unreported gene alterations and actionable targets.PMID 42569949Read ↗

Therapeutically Targetable Mutational Landscape of Anaplastic Thyroid Cancer.Semantic proximity Read ↗

Identification of Targetable Lesions in Anaplastic Thyroid Cancer by Genome ProfilingSemantic proximity Read ↗

Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAF(V600E) Mutation-Prevalent Area.Semantic proximity Read ↗

Unique mutation patterns in anaplastic thyroid cancer identified by comprehensive genomic profilingSemantic proximity Read ↗

Clinical Application of Next-Generation Sequencing in Advanced Thyroid Cancers.Semantic proximity Read ↗

Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing.Semantic proximity Read ↗

Clinical actionability of molecular testing in advanced thyroid cancer: a real-world cohort study.Semantic proximity Read ↗

Mutational Landmarks in Anaplastic Thyroid Cancer: A Perspective of a New Treatment StrategySemantic proximity Read ↗

NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma.Semantic proximity Read ↗

The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.Semantic proximity Read ↗

Recent Progress of Genome Study for Anaplastic Thyroid CancerSemantic proximity Read ↗

Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.