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Article

Unique mutation patterns in anaplastic thyroid cancer identified by comprehensive genomic profiling

13 Feb 2019

Abstract excerpt

INTRODUCTION: Anaplastic thyroid cancer (ATC) is a highly aggressive thyroid cancer. Those ATC with genomic alterations (GAs) in TSC2, ALK, and BRAF may respond to targeted therapies. METHODS: Comprehensive genomic profiling on 90 ATC specimens identified base substitutions, short insertions and deletions, amplifications, copy number alterations, and genomic rearrangements in up to 315 cancer-related genes and 28...

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PMID: 30758123
DOI: 10.1002/hed.25634

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