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NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma.

European thyroid journal - 1 Jun 2025

Karimi Amir Hossein, Zeng Peter Yf, Cecchini Matthew, Barrett John W, Pan Harrison, Ying Shengjie, Le Nhi, Mymryk Joe S, Ailles Laurie E, Nichols Anthony C

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is among the most daunting entities in clinical oncology. Large-scale genomic studies of thyroid cancer within the last decade have uncovered a distinct set of recurrent somatic alterations implicated in the development, aggressiveness, and treatment resistance of ATC. The sequence of events leading to the development of ATC commonly begins with a tumorigenic mutation that...

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Identifiers

PMID: 40396891
DOI: 10.1530/ETJ-25-0057
PMCID: PMC12139604

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