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Article

Therapeutically Targetable Mutational Landscape of Anaplastic Thyroid Cancer.

JCO precision oncology - 1 Mar 2026

Qazi Murtaza, Ahsan Muhammad Danyal, Telvizian Talar, Laiacona Samuel, Ahmad Nadir, McHugh Terri

Abstract excerpt

PURPOSE: Anaplastic thyroid cancer (ATC) is a rare and highly aggressive malignancy with limited treatment options. Currently, the only US Food and Drug Administration-approved targeted therapies for ATC are directed at BRAF V600E mutations and NTRK fusions. This study aimed to characterize the somatic pathogenic gene variant (PGV) landscape of ATC to identify additional potentially actionable pathways. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41849729
DOI: 10.1200/PO-25-00655

Genes

BRAF
AKT1
EIF1AX
KRAS
NRAS
PIK3CA
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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