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Article

TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain.

Blood - 19 Jun 2014

Reglińska-Matveyev Natalia, Andersson Helena M, Rezende Suely M, Dahlbäck Björn, Crawley James T B, Lane David A, Ahnström Josefin

Abstract excerpt

Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, composite or domain swap variants spanning the whole protein S molecule for their TFPI cofactor...

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Topics

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Share to Factor Xa
Share to Phospholipids
Share to Protein C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein S

Share to Sex Hormone-Binding Globulin

Share to Surface Plasmon Resonance

Share to Thrombin

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Source

Open in PubMed Open full text

Identifiers

PMID: 24740810
DOI: 10.1182/blood-2014-01-551812
PMCID: PMC4064334

Genes

TFPI
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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