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Article

Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.

Thrombosis and haemostasis - 1 May 2018

Takeyama Masahiro, Nogami Keiji, Sasai Kana, Furukawa Shoko, Shima Midori

Abstract excerpt

The link between factor (F)VIII and FX is essential for optimum activity of the tenase complex. The interactive site(s) in FVIII for FX remains to be completely clarified, however. We investigated the FVIII A2 domain-FX association that was speculated from inhibitory mechanism(s) by an anti-A2 autoantibody. SDS-PAGE demonstrated that the purified inhibitor IgG recognizing residues 373-562 blocked FXa cleavage at...

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PMID: 29614522
DOI: 10.1055/s-0038-1637745

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SDS
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