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Article

Interplay between PNPLA3 genotype, liver steatosis, and cardiac remodeling in young adults: A magnetic resonance imaging study.

Physiological reports - 1 Aug 2026

Lan Nick S R, Melton Phillip E, Sehly Amro, Adams Leon A, Olynyk John K, Ayonrinde Oyekoya T, Adler Brendan, Beilin Lawrence J, Mori Trevor A, Dwivedi Girish

Abstract excerpt

Steatotic liver disease (SLD) is associated with cardiovascular disease. The PNPLA3 rs738409C>G variant is a genetic determinant of liver fat accumulation. We investigated the association of the PNPLA3 rs738409C>G variant with cardiac structure and function in young adults, stratified by SLD status. Participants underwent genotyping at 17 years and liver and cardiac magnetic resonance imaging at 27 years. SLD was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42568180
DOI: 10.14814/phy2.71040
PMCID: PMC13451627

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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