Article
Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2025
Chen Yazhou, Laevens Benjamin P M, Lemainque Teresa, Müller-Franzes Gustav Anton, Seibel Tobias, Dlugosch Carola, Clusmann Jan, Koop Paul-Henry, Gong Rongpeng, Liu Yuanyuan, Jakhar Niharika, Cao Feng, Schophaus Simon, Raju Thriveni Basavanapura, Raptis Anastasia Artemis, van Haag Felix, Joy Joel, Loomba Rohit, Valenti Luca, Kather Jakob Nikolas, Brinker Titus J, Herzog Moritz, Costa Ivan G, Hernando Diego, Schneider Kai Markus, Truhn Daniel, Schneider Carolin V
Abstract excerpt
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting for the largest fraction of SLD heritability is PNPLA3 I148M, which is carried by 23% of the western population and increases the risk of SLD two to three-fold....
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