Integrating PNPLA3 into clinical risk prediction.

doi:10.1111/liv.16103

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Article

Integrating PNPLA3 into clinical risk prediction.

Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2025

Chen Vincent L, Vespasiani-Gentilucci Umberto

Abstract excerpt

The PNPLA3-rs738409-G variant was the first common variant associated with hepatic fat accumulation and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Nevertheless, to date, the clinical translation of this discovery has been minimal because it has not yet been clearly demonstrated where the genetic information may play an independent and additional role in clinical risk...

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Identifiers

PMID: 39282715
DOI: 10.1111/liv.16103
PMCID: PMC11815612

Genes

PNPLA3

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