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Article

High inherited risk predicts age-associated increases in fibrosis in patients with MASLD.

Journal of hepatology - 1 Oct 2025

Díaz Luis Antonio, Alazawi William, Agrawal Saaket, Arab Juan Pablo, Arrese Marco, Idalsoaga Francisco, Barreyro Fernando Javier, Gadano Adrian, Marciano Sebastián, Martínez Morales Jorge, Villela-Nogueira Cristiane, Leite Nathalie, Couto Claudia Alves, Theodoro Rafael, Monteiro Mísia Joyner de Sousa Dias, Oliveira Claudia P, Pessoa Mario G, Alvares-da-Silva Mario Reis, Madamba Egbert, Bettencourt Ricki, Richards Lisa M, Majithia Amit R, Khera Amit V, Loomba Rohit, Ajmera Veeral

Abstract excerpt

BACKGROUND & AIMS: Limited data have prevented routine genetic testing from being integrated into clinical practice in metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to quantify the effect of genetic variants on changes in fibrosis severity per decade in patients with MASLD. METHODS: This cross-sectional study included prospectively recruited adults with MASLD aged 18-70 who underwent...

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Source

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Identifiers

PMID: 40334848
DOI: 10.1016/j.jhep.2025.04.035
PMCID: PMC12453583

Genes

PNPLA3
HSD17B13
GCKR
IMPACT
MBOAT7
TM6SF2

Provenance

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High inherited risk predicts age-associated increases in fibrosis in patients with MASLD.PMID 40334848Read ↗

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