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Article

Growth Hormone and Cancer Risk: A Two-Sample Bidirectional Mendelian Randomization Study with Mediation Testing.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Yan Ze-Ming, Zou Yun-Zhi, Chen Yi-Guang, Cheng Jin-Tong, Yue Guang-Hao, Zhu Zhe, Deng Ze-Kun, Yu Jing-Ming, Wu Lu-Yao, Jiang Xiao-Bing, Tan Wen-Min, Li De-Pei

Abstract excerpt

INTRODUCTION: Growth Hormone (GH) therapy for deficiency carries potential cancer risks with unclear causality. This Mendelian randomization study investigated the relationship between genetically predicted GH levels and cancer risk across 16 types. METHODS: We selected genetic variants strongly associated with serum GH levels from published GWAS as instrumental variables. The primary analysis employed...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Neoplasms
Human Growth Hormone
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Polymorphism, Single Nucleotide

Male

Genetic Predisposition to Disease

Mediation Analysis

Source

Identifiers

PMID: 42565418
DOI: 10.2174/0118715303463853260710044412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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