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Systematic review of Mendelian randomization studies on risk of cancer.

BMC medicine - 2 Feb 2022

Markozannes Georgios, Kanellopoulou Afroditi, Dimopoulou Olympia, Kosmidis Dimitrios, Zhang Xiaomeng, Wang Lijuan, Theodoratou Evropi, Gill Dipender, Burgess Stephen, Tsilidis Konstantinos K

Abstract excerpt

BACKGROUND: We aimed to map and describe the current state of Mendelian randomization (MR) literature on cancer risk and to identify associations supported by robust evidence. METHODS: We searched PubMed and Scopus up to 06/10/2020 for MR studies investigating the association of any genetically predicted risk factor with cancer risk. We categorized the reported associations based on a priori designed levels of...

Topics

Causality
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Ovarian Neoplasms
Polymorphism, Single Nucleotide
Risk Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35105367
DOI: 10.1186/s12916-022-02246-y
PMCID: PMC8809022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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