Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study.

Abstract excerpt

BACKGROUND: Relationships between BMI and breast cancer risk have been widely reported in previous Mendelian randomization (MR) studies, but the underlying molecular mechanisms remain unclear. We conducted this comprehensive two-sample MR to investigate the mediating role of 8 circulating biomarkers linking genetically predicted BMI to breast cancer risk both individually and simultaneously. METHODS: A total of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomarkers, Tumor
• Share to Body Mass Index