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Article

Endocrine-disrupting chemical-induced gene networks confer coronary heart disease risk revealed by causal inference and single-cell analyses.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2026

Yao Tao, Lin Yun-Lu, Fang Luo-Xiang, Wang Yu-Tian, Zhou Lan-Feng, Zhang Ning, Chen Gang

Abstract excerpt

BACKGROUND: Endocrine-disrupting chemicals (EDCs) are linked to coronary heart disease (CHD), but underlying mechanisms remain unclear. We aimed to identify EDC-related genes and evaluate their causal roles in CHD. METHODS: We curated EDC-related genes from a compound-gene interaction database and integrated them with CHD genome-wide association study (GWAS) summary statistics and tissue-specific expression...

Read the complete abstract on PubMed

Topics

Humans
Gene Regulatory Networks
Endocrine Disruptors
Genome-Wide Association Study
Coronary Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Single-Cell Analysis

Quantitative Trait Loci

Mendelian Randomization Analysis

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42556777
DOI: 10.1016/j.fct.2026.116325

Genes

FCHO1
IPO9
RPL13
ZNF827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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