Article
Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.
Cell calcium - 1 Dec 2011
Giacomello Marta, De Mario Agnese, Lopreiato Raffaele, Primerano Simona, Campeol Mara, Brini Marisa, Carafoli Ernesto
Abstract excerpt
The inner ear converts sound waves into hearing signals through the mechanoelectrical transduction (MET) process. Deflection of the stereocilia bundle of hair cells causes the opening of channels that allow the entry of endolymph K(+) and Ca(2+). Ca(2+) that enters is crucial to the hearing process and is exported to the endolymph by the plasma membrane Ca(2+) pump (isoform PMCA2w/a): disturbances of the balance...
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