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Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

11 Feb 2021

Abstract excerpt

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression. Although the complete impact of GOF is still far from being fully understood, the effects on proliferation, migration, metabolic reprogramming, and immune evasion, among others, certainly...

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PMID: 33644030
DOI: 10.3389/fcell.2020.607670

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