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Article

A Shared Genetic Basis Underlying Myopia-Exotropia Comorbidity.

Investigative ophthalmology & visual science - 1 Jul 2026

Mi Yuze, Tao Zhe, Xue Zhengbo, Lin Shaokai, Huang Yebao, Zhu Qinnan, Zheng Xinni, Hong Yanggang, Liu Zirong, Tong Luyao, Zhou Jiawei, Wan Minghui

Abstract excerpt

Purpose: To characterize the shared genetic architecture underlying the frequent co-occurrence of myopia and exotropia. Methods: Leveraging large-scale genome-wide association study (GWAS) data, we examined the genetic correlation and polygenic overlap between myopia and exotropia. Candidate shared signals were prioritized through cross-trait meta-analysis using multi-trait analysis of GWAS (MTAG) and further...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42530915
DOI: 10.1167/iovs.67.8.61
PMCID: PMC13436582

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TSPAN10

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