Article
Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia.
JAMA ophthalmology - 1 Jun 2021
Tideman J Willem L, Pärssinen Olavi, Haarman Annechien E G, Khawaja Anthony P, Wedenoja Juho, Williams Katie M, Biino Ginevra, Ding Xiaohu, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Cheng Ching-Yu, Jonas Jost B, Young Terri L, Bailey-Wilson Joan E, Rahi Jugnoo, Williams Cathy, He Mingguang, Mackey David A, Guggenheim Jeremy A
Abstract excerpt
IMPORTANCE: Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high myopia (HM) and to myopia and hyperopia. Addressing this question is fundamental to understanding the genetics of refractive error and has clinical relevance for genotype-based prediction of children at risk for HM and for identification of new therapeutic targets....
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